Samuel Cho has expertise in Oncology drug discovery, including target validation and translational biology in both industry (+9 yrs) and academia. His experiences include both antibody and small molecule drug development, with an emphasis on signal transduction, mechanism of action studies and biomarker validation. Mr. Cho received his M.S. in Biology; his B.S. in Biochemistry and Cell Biology and his B.A. in Psychology all from the University of California, San Diego, La Jolla, CA. Mr. Cho is a registered U.S. patent agent.
MacLaren A, Cho S, Ferreira R, and McLachlan K. Lumiliximab, an anti-CD23 targeted therapy, enhances apoptosis in CLL cells and CD23+ lymphoma cell lines when used in combination with CLL therapies. 2010 (In preparation).
Reyes C*, Wu X, Huang F, Cho S, Cao X, Flavier A, Boccia A, Virata C, Gamez J, Snyder W, Lugovskoy A, Demarest S, Joseph I, McLachlan K, Glaser S, MacLaren A, Miller B*. Production and Characterization of an IgG-like Tetravalent Antibody for Enhanced Therapeutic Efficacy. Manuscript in progress.
Egles C, Huet H, Dogan F, Cho S, Dong S, Smith A, Knight E, McLachlan K, Garlick J. Integrin-blocking antibodies delay keratinocyte re-epithelialization in a human three-dimensional wound healing model. PloS one 2010; 5(5):e10528.
Gabarra V, Cho S, Ramirez M, Ren Y, Chen LL, Cheung A, Cao X, Rennard R, Unruh KR, Graff CP, Browning B, Huet HA, McLachlan K. Antibodies directed to alpha6beta4 highlight the adhesive and signaling functions of the integrin in breast cancer cell lines. Cancer Biology and Therapy. 2010 March 8; 9(6):437-45.
Chen LL, Gabarra V, Cho S, Browning B, Cao X, Huet H, Cheung A, Morena R, Ramirez M, Shields M, Blake Pepinsky R, McLachlan K. Functional characterization of integrin alpha6beta4 adhesion interactions using soluble integrin constructs reveals the involvement of different functional domains in the beta4 subunit. Cell Commun Adhes. 2008 Nov; 15(4):317-31.
Michaelson JS, Cho S, Browning B, Zheng TS, Lincecum JM, Wang MZ, Hsu YM, Burkly LC. Tweak induces mammary epithelial branching morphogenesis. Oncogene. 2005 Apr 14;24(16):2613-24.
Cho SY, Klemke RL. Purification of Pseudopodia from Polarized Cells Reveals Dynamic Redistribution and Activation of Rac Through Assembly of CAS/Crk Scaffold. Journal of Cell Biology. 2002 February 18; 156 (4): 725-736.
Stupack DG, Cho SY, Klemke RL. Molecular signaling mechanisms of cell migration and invasion. Immunologic Response. 2000; 21(2-3):83-8. Review.
Cho SY, Klemke RL. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. Journal of Cell Biology. 2000 May 12; 275(19):14729-35.
Cho S. Development of RNA-enzyme directed against E2A-PBX1 and BCR-ABL and Development of a NGFR-based Reporter for use in Retroviral Vector Mediated Delivery Systems. Thesis. 1998.
Ibanez G*, Timple N*, Cho S, Boykin C, Yang C, Hong K, Colson B, Wei J, Daniels M, Pierce L, Dakappagari N, Zhang H, Tangri S, Phillips L, Storgard C, Lundgren K. BIIB021, a fully synthetic oral small molecule inhibitor of Hsp90, shows anti-tumor activity in multiple xenograft models. AACR 2009.
Zou S, Cho SY, Incardona F, Braslawsky G, Giri J, Pathan N. HMN-176, a novel microtubule inhibitor induces cell cycle arrest and p53-dependent apoptosis in solid tumor cell lines. 95th Annual Meeting of the American Society for Cancer Research, Orlando, Florida, 2004.
Daniels MJ, McLachlan KR, Cho SY, Sereno AJ, Shestowsky WS, Kloetzer WS, Giri JG, Rowe T, Peach R, Reff ME. Identification of a Novel Biomarker and Potential Therapeutic Target for the Diagnosis and Treatment of Ovarian Cancer. Keystone Meeting on Molecular Targets for Cancer Therapy, Banff, Alberta, 2003.
Klemke RL, Cho SY, Brahmbhatt AA. Temporal and spatial organization of cytoskeleton in leading pseudopodia and trailing rear compartment of polarized cells. Keystone Meeting on Cell Migration, Tahoe City, CA, 2001.
Brahmbhatt AA, Cho SY, Klemke RL. Role of ERK in lamellipodia extension in eukaryotic cells. Keystone Meeting on Cell Migration, Tahoe City, CA, 2001.